Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | STK4 | Q13043 | 1/20 | 0.32 |
| ▸ | STK3 | Q13188 | 1/20 | 0.32 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9430240 | 0.90 | HRH4 (0.39) | OPRK1HTR4 | |
| SCHEMBL9404530 | 0.90 | PDE4A (0.36) | OPRK1POLBHTR4PDE4APDE4B | |
| SCHEMBL7329892 | 0.89 | KDM4E (0.39) | OPRK1POLBUSP30LRRK2HTR4 | |
| SCHEMBL9430270 | 0.89 | OPRK1 (0.41) | OPRK1POLBUSP30HTR4GABRA1 | |
| SCHEMBL9404293 | 0.89 | USP30 (0.38) | OPRK1POLBUSP30HTR4KDM4E | |
| SCHEMBL9404490 | 0.88 | OPRK1 (0.35) | OPRK1POLBUSP30HTR4KDM4E | |
| SCHEMBL9404434 | 0.86 | HTR4 (0.34) | OPRK1HTR4GABRA1GABRA3GABRB2 | |
| SCHEMBL7321007 | 0.86 | HTR4 (0.43) | OPRK1POLBUSP30HTR4KDM4E | |
| SCHEMBL9429862 | 0.85 | HTR4 (0.34) | OPRK1POLBHTR4KDM4EHTT | |
| SCHEMBL9429875 | 0.85 | HTR4 (0.34) | OPRK1POLBHTR4KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371080-A | Central nervous system disorders | NOVO NORDISK A/S | 1994-12-06 | — | — | US | disclosed |
| EP-0619820-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-10-19 | — | — | EP | disclosed |
| WO-1993013103-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-07-08 | — | — | WO | disclosed |