Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 10/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404623 | 0.87 | GRIN2D (0.42) | PIM1PIM2KDM4ECMA1GRIN2D | |
| SCHEMBL9404641 | 0.81 | PARP1 (0.44) | PIM1PIM2PARP1ALDH1A1HPGD | |
| SCHEMBL9404646 | 0.80 | PARP1 (0.36) | PARP1 | |
| SCHEMBL9404620 | 0.80 | KDM4E (0.42) | KDM4EPARP1ALDH1A1GAALMNA | |
| Hydrochloric Acid SCHEMBL9404635 | 0.80 | PARP1 (0.42) | PIM1PIM2PARP1ALDH1A1HPGD | |
| SCHEMBL9404642 | 0.80 | PIM1 (0.41) | PIM1PIM2HPGDLMNA | |
| SCHEMBL9404640 | 0.76 | PIM1 (0.44) | PIM1PIM2KDM4EPARP1HSD17B10 | |
| SCHEMBL1908070 | 0.75 | MAPT (0.46) | PIM1PIM2KDM4EGRIN2DGRIN3B | |
| SCHEMBL22006353 | 0.74 | PIM1 (0.55) | PIM1PIM2KDM4ECMA1 | |
| SCHEMBL9404622 | 0.73 | GRIN2D (0.47) | PIM1PIM2KDM4EGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526588-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1994-03-09 | — | — | EP | claimed |
| EP-0526588-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1994-03-09 | — | — | EP | disclosed |
| EP-0526588-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE. | NOVO NORDISK AS (DK) | 1993-02-10 | — | — | EP | disclosed |
| US-5182279-A | Antiepileptic, anticonvulsant, anxiolytic, antiischemic | NOVO NORDISK A/S (DK) | 1993-01-26 | — | — | US | disclosed |
| WO-1991016325-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-10-31 | — | — | WO | disclosed |