Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | NGFR | P08138 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9404635 | 0.98 | PARP1 (0.42) | PARP1MAPTRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9404642 | 0.81 | PIM1 (0.41) | HPGDTYMSARPIM1PIM2 | |
| SCHEMBL9404646 | 0.81 | PARP1 (0.36) | PARP1TYMSDAO | |
| SCHEMBL9404644 | 0.81 | PIM1 (0.47) | PARP1ALDH1A1HPGDPIM1PIM2 | |
| SCHEMBL9404620 | 0.81 | KDM4E (0.42) | PARP1MAPTALDH1A1TYMSAR | |
| SCHEMBL9404640 | 0.78 | PIM1 (0.44) | PARP1MAPTPIM1PIM2 | |
| SCHEMBL1908070 | 0.77 | MAPT (0.46) | PARP1MAPTRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11543811 | 0.75 | PARP1 (0.50) | PARP1MAPTRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8664533 | 0.71 | RAB9A (0.52) | PARP1MAPTRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9404623 | 0.71 | GRIN2D (0.42) | PARP1MAPTSMN1; SMN2ALDH1A1GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526588-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1994-03-09 | — | — | EP | disclosed |
| EP-0526588-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE. | NOVO NORDISK AS (DK) | 1993-02-10 | — | — | EP | disclosed |
| US-5182279-A | Antiepileptic, anticonvulsant, anxiolytic, antiischemic | NOVO NORDISK A/S (DK) | 1993-01-26 | — | — | US | disclosed |
| WO-1991016325-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-10-31 | — | — | WO | disclosed |