Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404641 | 0.81 | PARP1 (0.44) | PIM1PIM2HPGDARTYMS | |
| SCHEMBL9404620 | 0.80 | KDM4E (0.42) | LMNAARTYMSMIF | |
| SCHEMBL9404646 | 0.80 | PARP1 (0.36) | TYMS | |
| SCHEMBL9404644 | 0.80 | PIM1 (0.47) | PIM1PIM2LMNAHPGD | |
| Hydrochloric Acid SCHEMBL9404635 | 0.80 | PARP1 (0.42) | PIM1PIM2HPGDARTYMS | |
| SCHEMBL9404640 | 0.76 | PIM1 (0.44) | PIM1PIM2MIF | |
| SCHEMBL22310755 | 0.76 | EPM2A (0.40) | PIM1PIM2CHEK1FLT3AURKA | |
| SCHEMBL1908070 | 0.75 | MAPT (0.46) | PIM1PIM2LMNAHPGD | |
| SCHEMBL9404636 | 0.74 | GRIN2D (0.32) | — | |
| SCHEMBL6238353 | 0.74 | PIM1 (0.44) | PIM1PIM2CHEK1FLT3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526588-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1994-03-09 | — | — | EP | claimed |
| EP-0526588-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1994-03-09 | — | — | EP | disclosed |
| EP-0526588-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE. | NOVO NORDISK AS (DK) | 1993-02-10 | — | — | EP | disclosed |
| US-5182279-A | Antiepileptic, anticonvulsant, anxiolytic, antiischemic | NOVO NORDISK A/S (DK) | 1993-01-26 | — | — | US | disclosed |
| WO-1991016325-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-10-31 | — | — | WO | disclosed |