Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11793898 | 0.83 | TDP1 (0.66) | TDP1HSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL21409271 | 0.81 | TDP1 (0.62) | TDP1HSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL30874166 | 0.81 | TDP1 (0.62) | TDP1HSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL30543603 | 0.81 | APEX1 (0.63) | TDP1HSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL9404784 | 0.81 | ALDH1A1 (0.45) | TDP1HSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL25338865 | 0.81 | APEX1 (0.63) | TDP1HSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL31306758 | 0.81 | TDP1 (0.62) | TDP1HSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL4826787 | 0.77 | MAPT (0.51) | TDP1HSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL4828295 | 0.77 | MAPT (0.51) | TDP1HSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL31055463 | 0.77 | ALDH1A1 (0.44) | TDP1HSD17B10ALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0296597-B1 | Hexa-cyclic compound | DAIICHI SEIYAKU CO (JP) | 1994-09-21 | — | — | EP | disclosed |
| US-5061795-A | ANTITUMOR AGENTS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1991-10-29 | — | — | US | disclosed |
| US-4939255-A | Hexa-cyclic camptothecin derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-07-03 | — | — | US | disclosed |
| EP-0296597-A2 | Hexa-cyclic compound | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1988-12-28 | — | — | EP | disclosed |