Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | USP8 | P40818 | 1/20 | 0.44 |
| ▸ | USP7 | Q93009 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27927948 | 0.84 | ALDH1A1 (0.67) | ALDH1A1HPGDGAASMN1; SMN2LMNA | |
| SCHEMBL839543 | 0.83 | GAA (0.67) | POLBAPEX1CASP6CTDSP1TDP1 | |
| SCHEMBL27927171 | 0.83 | MEN1 (0.53) | TDP1ALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL25027266 | 0.83 | ALDH1A1 (0.66) | POLBALDH1A1HPGDGAALMNA | |
| SCHEMBL1969337 | 0.82 | SIRT6 (0.58) | POLBAPEX1CASP6CTDSP1TDP1 | |
| SCHEMBL29979387 | 0.82 | GAA (0.69) | POLBAPEX1CASP6CTDSP1TDP1 | |
| SCHEMBL23043630 | 0.82 | GAA (0.69) | POLBAPEX1CASP6CTDSP1TDP1 | |
| SCHEMBL1842961 | 0.79 | ADRB1 (0.58) | POLBAPEX1CASP6CTDSP1TDP1 | |
| SCHEMBL3252577 | 0.79 | ALDH1A1 (0.66) | POLBAPEX1CASP6CTDSP1TDP1 | |
| SCHEMBL31177578 | 0.77 | ALDH1A1 (0.68) | POLBAPEX1CASP6CTDSP1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0296597-B1 | Hexa-cyclic compound | DAIICHI SEIYAKU CO (JP) | 1994-09-21 | — | — | EP | disclosed |
| US-5061795-A | ANTITUMOR AGENTS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1991-10-29 | — | — | US | disclosed |
| US-4939255-A | Hexa-cyclic camptothecin derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-07-03 | — | — | US | disclosed |
| EP-0296597-A2 | Hexa-cyclic compound | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1988-12-28 | — | — | EP | disclosed |