Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | DAO | P14920 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.54 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL307426 | 0.90 | MAP4K4 (0.60) | TSHRMAP4K4MMP3MMP2CA1 | |
| Hydrochloric Acid SCHEMBL15939679 | 0.88 | MAP4K4 (0.59) | TSHRMAP4K4MMP3MMP2CA1 | |
| Benzoic Acid SCHEMBL27841085 | 0.88 | TSHR (0.64) | TSHRDAONAPRTKAT6AALDH1A1 | |
| Benzoic Acid SCHEMBL28916073 | 0.88 | TSHR (0.64) | TSHRDAONAPRTKAT6AALDH1A1 | |
| SCHEMBL306753 | 0.87 | KMO (0.65) | KAT6AMAP4K4LMNAKMOXDH | |
| SCHEMBL8912728 | 0.85 | AR (0.48) | TSHRKAT6AMAP4K4ALDH1A1MAPT | |
| SCHEMBL9967905 | 0.85 | MAPT (0.60) | TSHRKAT6AALDH1A1LMNAMAPT | |
| SCHEMBL13063666 | 0.85 | MAPT (0.60) | TSHRKAT6AALDH1A1LMNAMAPT | |
| SCHEMBL13445156 | 0.85 | MAPT (0.60) | TSHRKAT6AALDH1A1LMNAMAPT | |
| SCHEMBL13063665 | 0.85 | MAPT (0.60) | TSHRKAT6AALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5334327-A | Nematic liquid crystal display device | THE SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTH IRELAND (GB) | 1994-08-02 | — | — | US | disclosed |
| US-5334327-A | Nematic liquid crystal display device | THE SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTH IRELAND (GB) | 1994-08-02 | — | — | US | disclosed |
| US-5156763-A | Liquid crystals | THE SECRETARY OF STATE FOR FOR DEFENCE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND (GB) | 1992-10-20 | — | — | US | disclosed |
| US-5156763-A | Liquid crystals | THE SECRETARY OF STATE FOR FOR DEFENCE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND (GB) | 1992-10-20 | — | — | US | disclosed |