Sugi Predict

Sugi Predict / Compounds / SCHEMBL306753

SCHEMBL306753

SCHEMBL306753

N#Cc1ccc(-c2cccc(C(=O)O)c2)cc1

nearest known ligand 0.67

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ KMO O15229 2/20 0.65
▸ KAT6A Q92794 2/20 0.60
▸ LMNA P02545 1/20 0.54
▸ GAA P10253 1/20 0.54
▸ RXRA P19793 2/20 0.53
▸ RXRB P28702 2/20 0.53
▸ SLC22A12 Q96S37 2/20 0.53
▸ XDH P47989 1/20 0.53
▸ ERN1 O75460 1/20 0.50
▸ ACMSD Q8TDX5 1/20 0.49
▸ MAP4K4 O95819 1/20 0.49
▸ MAOA P21397 1/20 0.48
▸ MAOB P27338 1/20 0.48
▸ MEP1B Q16820 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5529069 0.88 XDH (0.62) KMOKAT6ARXRARXRBSLC22A12
Benzoic Acid SCHEMBL9405473 0.87 TSHR (0.54) KMOKAT6ALMNASLC22A12XDH
SCHEMBL14683877 0.85 KMO (0.87) KMOLMNAGAARXRARXRB
SCHEMBL29577419 0.85 KMO (0.87) KMOLMNAGAARXRARXRB
SCHEMBL22801094 0.85 KAT6A (0.56) KMOKAT6ALMNAGAAXDH
SCHEMBL3721296 0.85 KAT6A (0.56) KAT6AERN1MAOAMAOB
SCHEMBL2516130 0.84 DHODH (0.53) KAT6ARXRARXRBSLC22A12XDH
SCHEMBL12171984 0.84 NPC1 (0.59) KAT6AMAOAMAOB
SCHEMBL3220396 0.83 KMO (0.91) KMOLMNAGAARXRARXRB
Biphenyl SCHEMBL9652651 0.83 KMO (0.91) KMOLMNAGAARXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1789416-B1 AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS HOFFMANN LA ROCHE (CH) 2009-03-11 — — EP claimed
US-20070232611-A1 Amide Derivatives of 3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents F. HOFFMANN-LA ROCNE AG (CH) 2007-10-04 — — US claimed
EP-1789417-A1 AMIDE DERIVATIVES OF 7-AMINO-3-PHENYL-DIHYDROPYRIMIDO [4,5-d]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-05-30 — — EP claimed
EP-1789416-A2 AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F. Hoffmann-la Roche AG (CH) 2007-05-30 — — EP claimed
WO-2006024486-A2 AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2006-03-09 — — WO claimed
WO-2006024487-A1 AMIDE DERIVATIVES OF 7-AMINO-3-PHENYL-DIHYDROPYRIMIDO [4,5-d]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2006-03-09 — — WO claimed
US-11629141-B2 Proteasome inhibitors and uses thereof CORNELL UNIVERSITY (US) 2023-04-18 — — US disclosed
EP-4006012-A1 PROTEASOME INHIBITORS AND USES THEREOF Cornell University (US) 2022-06-01 — — EP disclosed
EP-3402799-B1 HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS ENANTA PHARM INC (US) 2022-05-04 — — EP disclosed
CN-114306297-A Proteasome inhibitors and uses thereof 康奈尔大学 2022-04-12 — — CN disclosed
CN-108351169-B Proteasome inhibitors and uses thereof 康奈尔大学 2022-01-28 — — CN disclosed
EP-3362754-B1 PROTEASOME INHIBITORS AND USES THEREOF UNIV CORNELL (US) 2021-12-22 — — EP disclosed
US-11066397-B2 Proteasome inhibitors and uses thereof CORNELL UNIVERSITY (US) 2021-07-20 — — US disclosed
US-20070232611-A1 Amide Derivatives of 3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents F. HOFFMANN-LA ROCNE AG (CH) 2007-10-04 — — US disclosed
EP-1789417-A1 AMIDE DERIVATIVES OF 7-AMINO-3-PHENYL-DIHYDROPYRIMIDO [4,5-d]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-05-30 — — EP disclosed
EP-1789416-A2 AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F. Hoffmann-la Roche AG (CH) 2007-05-30 — — EP disclosed
WO-2006024486-A2 AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2006-03-09 — — WO disclosed
WO-2006024487-A1 AMIDE DERIVATIVES OF 7-AMINO-3-PHENYL-DIHYDROPYRIMIDO [4,5-d]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2006-03-09 — — WO disclosed
US-5591769-A PYRROLIDINE DERIVATIVES; ANTICOAGULANTS KARL THOMAE GMBH (DE) 1997-01-07 — — US disclosed
US-5541343-A ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS KARL THOMAE GMBH (DE) 1996-07-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11066397-B2 Proteasome inhibitors and uses thereof PSMB5, PSMB1, PSMB10 KMO 744/4885KAT6A 575/4885LMNA 3466/4885
US-20070232611-A1 Amide Derivatives of 3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents DPYD, THPO, DHPS KMO 1002/4885KAT6A 3193/4885LMNA 4475/4885
US-11629141-B2 Proteasome inhibitors and uses thereof PSMB5, PSMB1, PSMB10 KMO 764/4885KAT6A 547/4885LMNA 3303/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.