SCHEMBL8912728

SCHEMBL8912728

C[SiH](C)c1ccc(C(=O)O)cc1.N#Cc1ccc(-c2ccccc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.48
MAP4K4 O95819 1/20 0.48
EGFR P00533 1/20 0.45
TAS2R14 Q9NYV8 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
MAPT P10636 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
KAT6A Q92794 1/20 0.43
SLC22A12 Q96S37 2/20 0.43
XDH P47989 1/20 0.43
ALDH1A1 P00352 1/20 0.43
TSHR P16473 1/20 0.43
PDE4B Q07343 1/20 0.42
PDE4D Q08499 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
NR3C2 P08235 1/20 0.42
GRIA2 P42262 1/20 0.42
GRIA4 P48058 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzoic Acid SCHEMBL9405473 0.85 TSHR (0.54) MAP4K4EGFRTAS2R14NPC1RAB9A
Biphenyl SCHEMBL8913858 0.85 EGFR (0.53) EGFRNPC1RAB9AMAPTSMN1; SMN2
SCHEMBL307426 0.83 MAP4K4 (0.60) ARMAP4K4SLC22A12XDHTSHR
Hydrochloric Acid SCHEMBL15939679 0.82 MAP4K4 (0.59) ARMAP4K4SLC22A12XDHTSHR
SCHEMBL27893882 0.82 BCL2L1 (0.56) EGFRSMN1; SMN2ALDH1A1TSHRCA1
SCHEMBL4828278 0.81 ALDH1A1 (0.59) ARMAP4K4TAS2R14NPC1RAB9A
SCHEMBL4826432 0.78 RARB (0.57) ARTAS2R14NPC1RAB9AMAPT
Acetic Acid SCHEMBL28953609 0.78 MMP3 (0.54) MAPTSMN1; SMN2KAT6AALDH1A1TSHR
SCHEMBL216706 0.78 CA2 (0.64) ARMAP4K4TAS2R14MAPTSLC22A12
SCHEMBL8912234 0.77 CA1 (0.62) MAP4K4NPC1RAB9AMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE35462-E Silylated benzoic acid derivatives CONSORTIUM FUR ELEKOCHEMISCHE IND. GMBH (DE) 1997-02-25 US disclosed
US-5277838-A Silylated benzoic acid derivatives CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1994-01-11 US disclosed
US-5106530-A Liquid crystals Consortium Fur Elektrochemische Ind. (DE) 1992-04-21 US disclosed