Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | CASP1 | P29466 | 1/20 | 0.62 |
| ▸ | CASP7 | P55210 | 1/20 | 0.62 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.62 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844925 | 0.95 | POLB (0.81) | POLBALDH1A1CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL10394217 | 0.94 | POLB (0.78) | POLBALDH1A1CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL16084377 | 0.94 | POLB (0.78) | POLBALDH1A1CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL4222552 | 0.94 | POLB (0.78) | POLBALDH1A1CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL21765989 | 0.91 | POLB (0.77) | POLBALDH1A1CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL516379 | 0.91 | POLB (1.00) | POLBALDH1A1CYP3A4CYP2C19CYP1A2 | |
| Theophylline Anhydrous SCHEMBL10759281 | 0.89 | POLB (0.66) | POLBALDH1A1CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL8595449 | 0.87 | POLB (0.71) | POLBALDH1A1CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL6243622 | 0.87 | ALDH1A1 (0.71) | POLBALDH1A1CYP3A4CYP2C19CYP1A2 | |
| Hydrochloric Acid SCHEMBL6496307 | 0.85 | POLB (0.69) | POLBALDH1A1CYP3A4CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106995797-A | Monoclonal antibody STRO 4 | 中胚有限公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-104678106-B | monoclonal antibody STRO-4 | 中胚有限公司 | 2016-12-07 | — | — | CN | disclosed |
| CN-104678106-A | Monoclonal antibody STRO-4 | MESOBLAST INC | 2015-06-03 | — | — | CN | disclosed |
| CN-102257388-B | Monoclonal antibody stro-4 | ANGIOBLAST SYSTEMS INC | 2015-03-18 | — | — | CN | disclosed |
| CN-102257388-A | Monoclonal antibody stro-4 | ANGIOBLAST SYSTEMS INC | 2011-11-23 | — | — | CN | disclosed |
| US-5332744-A | Hypotensive, congestive heart failure, intraocular pressure | MERCK & CO., INC. (US) | 1994-07-26 | — | — | US | disclosed |
| US-5157026-A | Oxo-purines as angiotensin II antagonists | MERCK & CO., INC. (US) | 1992-10-20 | — | — | US | disclosed |
| WO-1992007852-A1 | BIPHENYLALKYL XANTHINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |
| US-5102880-A | Biphenyl imidazotriazine derivatives; Hypotensive and cardiotonic agents | MERCK & CO., INC. (US) | 1992-04-07 | — | — | US | disclosed |
| EP-0430300-A2 | Xanthine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-06-05 | — | — | EP | disclosed |