Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 10/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | EEF2K | O00418 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9406790 | 0.82 | NPC1 (0.74) | NPC1MAPTACHEKDM4EALDH1A1 | |
| SCHEMBL9406604 | 0.72 | NPC1 (0.46) | NPC1MAPTACHEKDM4EALDH1A1 | |
| SCHEMBL9455514 | 0.72 | KDM4E (0.52) | NPC1MAPTACHEKDM4EALDH1A1 | |
| SCHEMBL9406553 | 0.71 | KDM4E (0.41) | NPC1MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9406649 | 0.68 | NPC1 (0.43) | NPC1MAPTACHEKDM4EALDH1A1 | |
| SCHEMBL5117887 | 0.67 | NPC1 (0.53) | NPC1MAPTACHEKDM4EALDH1A1 | |
| SCHEMBL5083088 | 0.67 | TUBB4A (0.39) | NPC1MAPTKDM4EALDH1A1RAB9A | |
| SCHEMBL4727819 | 0.66 | NSD2 (0.38) | KDM4EALDH1A1SMN1; SMN2POLBTP53 | |
| SCHEMBL4729403 | 0.66 | SLC10A2 (0.38) | KDM4EALDH1A1SMN1; SMN2TP53HSD17B10 | |
| SCHEMBL5114888 | 0.65 | NPC1 (0.50) | NPC1MAPTACHEKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0328535-B1 | THE ADMINISTRATION OF MONOAMINE ACRIDINES IN CHOLINERGIC NEURONAL DEFICIT STATES | SUMMERS WILLIAM KOOPMANS (US) | 1994-06-01 | — | — | EP | disclosed |
| EP-0595365-A1 | Pharmaceutical composition for the treatment of underlying nonpharmacologically induced nervous system cholinergic deficit state comprising monoamine acridine derivatives | Summers, William Koopmans (US) | 1994-05-04 | — | — | EP | disclosed |
| US-4816456-A | Administration of monoamine acridines in cholinergic neuronal deficit states | SUMMERS WILLIAM K (US) | 1989-03-28 | — | — | US | disclosed |