Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | CDC25B | P30305 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.52 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12913003 | 0.90 | TDP1 (0.45) | ALDH1A1CDC25BCASP6RCE1MCL1 | |
| SCHEMBL940556 | 0.87 | ALDH1A1 (0.57) | ALDH1A1MCL1BCL2A1TDP1L3MBTL1 | |
| SCHEMBL940642 | 0.84 | FFAR1 (0.44) | ALDH1A1TDP1L3MBTL1LMNAFOLH1 | |
| SCHEMBL23908388 | 0.79 | ALDH1A1 (0.49) | ALDH1A1CDC25BMCL1FOLH1SMN1; SMN2 | |
| SCHEMBL14700255 | 0.78 | TDP1 (0.44) | TDP1L3MBTL1LMNATSHRSPHK1 | |
| SCHEMBL29167354 | 0.77 | ALDH1A1 (0.47) | ALDH1A1CDC25BMCL1FOLH1SMN1; SMN2 | |
| SCHEMBL30722451 | 0.77 | ALDH1A1 (0.47) | ALDH1A1CDC25BMCL1BCL2A1FOLH1 | |
| SCHEMBL25170829 | 0.77 | ALDH1A1 (0.78) | ALDH1A1CDC25BCASP6RCE1MCL1 | |
| SCHEMBL30291197 | 0.77 | ALDH1A1 (0.78) | ALDH1A1CDC25BCASP6RCE1MCL1 | |
| SCHEMBL23827446 | 0.76 | ALDH1A1 (0.43) | ALDH1A1MCL1BCL2A1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776345-B1 | Method of preparing N2-functionalised indazolinone derivatives | UNIV ST ANDREWS (GB) | 2013-02-13 | — | — | EP | disclosed |
| US-7868184-B2 | Multicore indazolinone library | The University of the University of St. Andrews (GB) | 2011-01-11 | — | — | US | disclosed |
| US-20070179294-A1 | Multicore indazolinone library | THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2007-08-02 | — | — | US | disclosed |
| EP-1776345-A2 | A MULTICORE INDAZOLINONE LIBRARY | The University Court of the University of St. Andrews (GB) | 2007-04-25 | — | — | EP | disclosed |
| WO-2005121096-A2 | A MULTICORE INDAZOLINONE LIBRARY | THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179294-A1 | Multicore indazolinone library | IPMK, TTK, IWS1 | ALDH1A1 1887/4885CDC25B 379/4885CASP6 2692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.