Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CAMK2A | Q9UQM7 | 3/20 | 0.37 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.37 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.37 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL939319 | 0.84 | NAPRT (0.34) | MAPTALDH1A1DGAT1 | |
| SCHEMBL9899656 | 0.82 | HTT (0.36) | ALDH1A1CA2 | |
| SCHEMBL5249119 | 0.82 | AKR1B1 (0.44) | AKR1B1TDP1CXCL8CYP1A2KDM4E | |
| SCHEMBL30034504 | 0.81 | ALDH1A1 (0.42) | AKR1B1TDP1KDM4EALDH1A1PTGS2 | |
| SCHEMBL20565701 | 0.81 | ALDH1A1 (0.42) | AKR1B1TDP1KDM4EALDH1A1PTGS2 | |
| SCHEMBL22983470 | 0.81 | AKR1B1 (0.38) | AKR1B1TDP1CXCL8CYP1A2KDM4E | |
| SCHEMBL29862772 | 0.81 | AKR1B1 (0.38) | AKR1B1TDP1CXCL8CYP1A2KDM4E | |
| SCHEMBL9898867 | 0.81 | AKR1B1 (0.38) | AKR1B1TDP1CXCL8CYP1A2KDM4E | |
| SCHEMBL15940531 | 0.81 | FFAR1 (0.43) | ALDH1A1ADRA1AKEAP1 | |
| SCHEMBL838041 | 0.78 | ALDH1A1 (0.44) | KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114369082-B | Pyridine substituted spiro compounds and application thereof in preparation of anti-plant virus agent | 贵州大学 | 2023-09-05 | — | — | CN | claimed |
| CN-114369082-A | Pyridine substituted spiro compound, preparation method thereof and application thereof in preparation of anti-plant virus medicament | 贵州大学 | 2022-04-19 | — | — | CN | claimed |
| EP-3810275-B1 | 2,3-DIHYDROFURO[2,3-B]PYRIDINE COMPOUNDS | LILLY CO ELI (US) | 2023-10-04 | — | — | EP | disclosed |
| CN-114369082-B | Pyridine substituted spiro compounds and application thereof in preparation of anti-plant virus agent | 贵州大学 | 2023-09-05 | — | — | CN | disclosed |
| CN-112312969-B | 2, 3-dihydrofuro [2,3-b ] pyridine compounds | 伊莱利利公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-114369082-A | Pyridine substituted spiro compound, preparation method thereof and application thereof in preparation of anti-plant virus medicament | 贵州大学 | 2022-04-19 | — | — | CN | disclosed |
| US-11214576-B2 | 2,3-dihydrofuro[2,3-b]pyridine compounds | ELI LILLY AND COMPANY (US) | 2022-01-04 | — | — | US | disclosed |
| US-11214576-B2 | 2,3-dihydrofuro[2,3-b]pyridine compounds | ELI LILLY AND COMPANY (US) | 2022-01-04 | — | — | US | disclosed |
| EP-3810275-A1 | 2,3-DIHYDROFURO[2,3-B]PYRIDINE COMPOUNDS | Eli Lilly and Company (US) | 2021-04-28 | — | — | EP | disclosed |
| US-20210070766-A1 | 2,3-DIHYDROFURO[2,3-B]PYRIDINE COMPOUNDS | ELI LILLY AND COMPANY | 2021-03-11 | — | — | US | disclosed |
| US-20210070766-A1 | 2,3-DIHYDROFURO[2,3-B]PYRIDINE COMPOUNDS | ELI LILLY AND COMPANY | 2021-03-11 | — | — | US | disclosed |
| WO-2012078608-A1 | PREPARATION OF PHANTASMIDINE AND ANALOGUES THEREOF | BRANDEIS UNIVERSITY (US) | 2012-06-14 | — | — | WO | disclosed |
| US-20120149851-A1 | SEPARATING AGENT FOR OPTICAL ISOMERS | NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) | 2012-06-14 | — | — | US | disclosed |
| CN-101990541-A | Fused heteroaryl modulators of glucocorticoid receptor, ap-1, and/or nf-kb activity and use thereof | BRISTOL MYERS SQUIBB CO | 2011-03-23 | — | — | CN | disclosed |
| US-20110021351-A1 | HERBICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-20110021351-A1 | HERBICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-20110021351-A1 | HERBICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| EP-2254416-A2 | HERBICIDAL COMPOUNDS | Syngenta Limited (GB) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009090402-A2 | HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2009-07-23 | — | — | WO | disclosed |
| WO-2009090402-A2 | HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2009-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11214576-B2 | 2,3-dihydrofuro[2,3-b]pyridine compounds | PSEN2, PSEN1, PARK7 | AKR1B1 243/4885TDP1 1181/4885CXCL8 4505/4885 |
| US-20110021351-A1 | HERBICIDAL COMPOUNDS | DDT, CBR3, TH | AKR1B1 195/4885TDP1 550/4885CXCL8 4835/4885 |
| US-20210070766-A1 | 2,3-DIHYDROFURO[2,3-B]PYRIDINE COMPOUNDS | PSEN2, PSEN1, PARK7 | AKR1B1 243/4885TDP1 1181/4885CXCL8 4505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.