Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 4/20 | 0.56 |
| ▸ | MME | P08473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16464700 | 1.00 | XIAP (0.56) | XIAPACEMME | |
| SCHEMBL9409870 | 1.00 | XIAP (0.56) | XIAPACEMME | |
| SCHEMBL16465568 | 1.00 | XIAP (0.56) | XIAPACEMME | |
| SCHEMBL7814933 | 0.90 | XIAP (0.59) | XIAPACE | |
| SCHEMBL5377148 | 0.90 | ACE (0.60) | ACEMME | |
| SCHEMBL17044930 | 0.84 | XIAP (0.54) | XIAPACE | |
| SCHEMBL16466352 | 0.84 | XIAP (0.54) | XIAPACE | |
| SCHEMBL16466347 | 0.84 | XIAP (0.54) | XIAPACE | |
| SCHEMBL7269341 | 0.84 | ACE (0.57) | XIAPACEMME | |
| SCHEMBL3729400 | 0.84 | ACE (0.57) | XIAPACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906535-B1 | INDOLINES | HOFFMANN LA ROCHE (CH) | 2018-08-08 | — | — | EP | disclosed |
| US-9403768-B2 | Indolines | HOFFMANN-LA ROCHE INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-20150246882-A1 | INDOLINES | HOFFMANN-LA ROCHE INC. | 2015-09-03 | — | — | US | disclosed |
| EP-2906535-A1 | INDOLINES | F. Hoffmann-La Roche AG (CH) | 2015-08-19 | — | — | EP | disclosed |
| WO-2014056755-A1 | INDOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-17 | — | — | WO | disclosed |
| EP-0618221-A2 | Heterocyclic inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-10-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246882-A1 | INDOLINES | IDO1, INMT, CCNY | XIAP 1780/4885ACE 3374/4885MME 3175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.