Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16464700 | 0.90 | XIAP (0.56) | ACEMME | |
| SCHEMBL16465568 | 0.90 | XIAP (0.56) | ACEMME | |
| SCHEMBL9409870 | 0.90 | XIAP (0.56) | ACEMME | |
| SCHEMBL9409863 | 0.90 | XIAP (0.56) | ACEMME | |
| SCHEMBL5837686 | 0.90 | ACE (0.49) | ACEMME | |
| SCHEMBL5917460 | 0.90 | ACE (0.49) | ACEMME | |
| SCHEMBL5568411 | 0.87 | ACE (0.55) | ACEMME | |
| SCHEMBL9543558 | 0.86 | ACE (0.52) | ACEMME | |
| SCHEMBL9543550 | 0.86 | ACE (0.52) | ACEMME | |
| SCHEMBL13895644 | 0.85 | ACE (0.53) | ACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288661-B2 | Process for the synthesis of (2S,3aS,7aS)-1-[(S)-alanyl]-octahydro-1H-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | LES LABORATOIRES SERVIER (FR) | 2007-10-30 | — | — | US | disclosed |
| US-20070123581-A1 | Process for the synthesis of (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | LES LABORATOIRES SERVIER (FR) | 2007-05-31 | — | — | US | disclosed |
| US-7223872-B2 | Process for the synthesis of perindopril and its pharmaceutically acceptable salts | LES LABORATOIRES SERVIER (FR) | 2007-05-29 | — | — | US | disclosed |
| US-20070088168-A1 | PROCESS FOR THE SYNTHESIS OF PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | LES LABORATOIRES SERVIER (FR) | 2007-04-19 | — | — | US | disclosed |
| EP-1256590-B1 | Method for synthesis of (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indole-2- carboxylic acid derivatives and use in the synthesis of perindopril | SERVIER LAB (FR) | 2006-03-01 | — | — | EP | disclosed |
| EP-1319668-B1 | Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril | SERVIER LAB (FR) | 2004-10-27 | — | — | EP | disclosed |
| WO-2004082357-A2 | NOVEL METHOD FOR THE SYNTHESIS OF DERIVATIVES OF (2S, 3AS, 7AS)-1-[(S)-ALANYL]-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID AND APPLICATION THEREOF TO THE SYNTHESIS OF PERINDOPRIL | LES LABORATOIRES SERVIER (FR) | 2004-09-30 | — | — | WO | disclosed |
| EP-1420030-A2 | Method for synthesis of (2S,3aS,7aS)-1-[(S)-alanyl]-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril | Les Laboratoires Servier (FR) | 2004-05-19 | — | — | EP | disclosed |
| EP-1403277-A1 | Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril | LES LABORATOIRES SERVIER (FR) | 2004-03-31 | — | — | EP | disclosed |
| EP-1380590-A1 | Method for synthesis of perindopril and its pharmaceutically acceptable salts | Les Laboratoires Servier (FR) | 2004-01-14 | — | — | EP | disclosed |
| EP-1380591-A1 | Method for synthesis of perindopril and its pharmaceutically acceptable salts | Les Laboratoires Servier (FR) | 2004-01-14 | — | — | EP | disclosed |
| EP-1371659-A1 | Method for synthesis of perindopril and its pharmaceutically acceptable salts [2003/26] | Les Laboratoires Servier (FR) | 2003-12-17 | — | — | EP | disclosed |
| EP-1319668-A1 | Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril | Les Laboratoires Servier (FR) | 2003-06-18 | — | — | EP | disclosed |
| EP-1256590-A1 | Method for synthesis of (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indole-2- carboxylic acid derivatives and use in the synthesis of perindopril | Les Laboratoires Servier S.A. (FR) | 2002-11-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088168-A1 | PROCESS FOR THE SYNTHESIS OF PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | ACE, REN, QDPR | ACE 1/4885MME 290/4885 |
| US-20070123581-A1 | Process for the synthesis of (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | CYP2S1, TPH1, AGTR1 | ACE 10/4885MME 996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.