Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.33 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.31 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.31 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19251713 | 0.78 | TLR2 (0.39) | CETPKDM4EPPARGEPHX2ALDH1A1 | |
| SCHEMBL19251687 | 0.75 | PPARG (0.38) | CETPKDM4EPPARGEPHX2ALDH1A1 | |
| SCHEMBL19251699 | 0.73 | MAPT (0.39) | CETPKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL17629532 | 0.69 | ALDH1A1 (0.37) | CETPKDM4EPPARGEPHX2ALDH1A1 | |
| SCHEMBL17629533 | 0.67 | TRPM2 (0.36) | CETPKDM4EPPARGEPHX2ALDH1A1 | |
| SCHEMBL17629556 | 0.66 | PPARG (0.35) | CETPPPARGEPHX2MAPT | |
| SCHEMBL941457 | 0.63 | EGLN1 (0.45) | TEAD1KDM4EALDH1A1PRKAB2PRKAG1 | |
| SCHEMBL17629585 | 0.63 | CETP (0.43) | CETPKDM4EPPARGALDH1A1MAPT | |
| SCHEMBL17629564 | 0.62 | PPARG (0.35) | CETPKDM4EPPARGEPHX2ALDH1A1 | |
| SCHEMBL17629562 | 0.62 | CACNA1F (0.36) | CETPKDM4EPPARGEPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257171-B1 | TETRAHYDRO-1H-PYRROLO-FUSED PYRIDONES | MERCK SHARP & DOHME (US) | 2016-02-10 | — | — | EP | disclosed |
| US-8372863-B2 | Tetrahydro-1H-pyrrolo fused pyridones | MERCK SHARP & DOHME CORP. (US) | 2013-02-12 | — | — | US | disclosed |
| US-20110009406-A1 | TETRAHYDRO-1H-PYRROLO FUSED PYRIDONES | MERCK SHARP & DOHME LLC | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009406-A1 | TETRAHYDRO-1H-PYRROLO FUSED PYRIDONES | HIF1AN, EGLN2, EGLN3 | CETP 4627/4885HRH3 414/4885BCL2A1 3016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.