Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.67 |
| ▸ | BCHE | P06276 | 3/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9411574 | 1.00 | ACHE (0.67) | ACHEBCHEFAAH | |
| Maleic Acid SCHEMBL9411431 | 0.95 | ACHE (0.68) | ACHEBCHEFAAH | |
| Fumaric Acid SCHEMBL9411435 | 0.95 | ACHE (0.68) | ACHEBCHEFAAH | |
| Fumaric Acid SCHEMBL9411586 | 0.95 | ACHE (0.68) | ACHEBCHEFAAH | |
| SCHEMBL9411436 | 0.92 | ACHE (0.78) | ACHE | |
| Maleic Acid SCHEMBL9411410 | 0.89 | ACHE (0.84) | ACHEBCHE | |
| Fumaric Acid SCHEMBL6989955 | 0.89 | ACHE (0.84) | ACHEBCHE | |
| Fumaric Acid SCHEMBL6989960 | 0.89 | ACHE (0.84) | ACHEBCHE | |
| SCHEMBL9411273 | 0.87 | ACHE (0.79) | ACHEBCHE | |
| Fumaric Acid SCHEMBL9411527 | 0.86 | ACHE (0.55) | ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0602242-A1 | BENZISOXAZOLE COMPOUND AND USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |