Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | UBE2N | P61088 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7057695 | 0.81 | KDM4E (0.62) | KDM4EALDH1A1HPGDPKMMAPT | |
| SCHEMBL9412635 | 0.80 | KDM4E (0.46) | KDM4EALDH1A1HPGDPKMMAPT | |
| SCHEMBL25090486 | 0.80 | ADORA2B (0.68) | KDM4EALDH1A1HPGDADORA2AADORA2B | |
| SCHEMBL5437075 | 0.74 | KDM4E (0.41) | KDM4EALDH1A1HPGDPKMMAPT | |
| SCHEMBL5449103 | 0.74 | KDM4E (0.41) | KDM4EALDH1A1HPGDPKMMAPT | |
| SCHEMBL6876786 | 0.71 | GAA (0.58) | KDM4EALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL5642013 | 0.70 | MEN1 (0.55) | ALDH1A1MAPTNPSR1TSHRMAPK1 | |
| SCHEMBL9287667 | 0.70 | KDM4E (0.38) | KDM4EALDH1A1HPGDPKMMAPT | |
| SCHEMBL16598824 | 0.68 | SMN1; SMN2 (0.47) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL18865648 | 0.67 | CYP11B2 (0.45) | ALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611660-A2 | Condensed 5-membered heterocycles, process for their preparation and medicines containing these compounds | Dr. Karl Thomae GmbH (DE) | 1994-08-24 | — | — | EP | disclosed |