Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.39 |
| ▸ | KDM5A | P29375 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 3/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11888786 | 0.92 | CD38 (0.37) | KDM4ESMN1; SMN2TSHRMAPK10RAB9A | |
| SCHEMBL11888799 | 0.91 | KDM4C (0.38) | KDM4CKDM5BKDM5AKDM4EALDH1A1 | |
| SCHEMBL11888808 | 0.89 | KDM4C (0.37) | KDM4CKDM5BKDM5AKDM4EALDH1A1 | |
| SCHEMBL940180 | 0.85 | ALDH1A1 (0.38) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL939861 | 0.83 | LMNA (0.32) | KDM4CKDM5BKDM5AALDH1A1MEN1 | |
| SCHEMBL938392 | 0.83 | KDM4C (0.40) | KDM4CKDM5BKDM5AKDM4EALDH1A1 | |
| SCHEMBL938974 | 0.83 | KDM5A (0.34) | KDM4CKDM5BKDM5AKDM4EALDH1A1 | |
| SCHEMBL941264 | 0.82 | KDM4C (0.41) | KDM4CKDM5BKDM5AKDM4EALDH1A1 | |
| SCHEMBL938620 | 0.81 | KDM4C (0.38) | KDM4CKDM5BKDM5AKDM4EALDH1A1 | |
| SCHEMBL940188 | 0.81 | CLCN2 (0.38) | KDM4CKDM5BKDM5AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440542-B1 | Substituted benzimidazoles, benzonthiazoles and benzoxazoles | GRUENENTHAL GMBH (DE) | 2013-12-18 | — | — | EP | disclosed |
| US-8232288-B2 | Substituted benzimidazoles, benzothiazoles and benzoxazoles | GRUENENTHAL GMBH (DE) | 2012-07-31 | — | — | US | disclosed |
| US-20110009382-A1 | Substituted Benzimidazoles, Benzothiazoles and Benzoxazoles | GRUENENTHAL GMBH (DE) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009382-A1 | Substituted Benzimidazoles, Benzothiazoles and Benzoxazoles | BDKRB1, BDKRB2, BRD1 | KDM4C 3227/4885KDM5B 2301/4885KDM5A 2668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.