Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 16/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9412588 | 0.85 | TNF (0.57) | TNFMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL4251174 | 0.84 | TNF (0.56) | TNFCYP1A2 | |
| SCHEMBL13746093 | 0.77 | TNF (0.40) | TNF | |
| SCHEMBL1546702 | 0.75 | CASP6 (0.50) | MEN1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL9412552 | 0.73 | TNF (0.53) | TNFALDH1A1HPGD | |
| SCHEMBL9729840 | 0.72 | ALDH1A1 (0.45) | TNFMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL11210331 | 0.70 | TNF (0.58) | TNFALDH1A1CYP1A2 | |
| SCHEMBL17682312 | 0.69 | TNF (1.00) | TNFMAPTCYP1A2 | |
| SCHEMBL4255826 | 0.69 | CASP6 (0.46) | TNFMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL7743865 | 0.68 | PDE4A (0.42) | ALDH1A1MAPTCASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611660-A2 | Condensed 5-membered heterocycles, process for their preparation and medicines containing these compounds | Dr. Karl Thomae GmbH (DE) | 1994-08-24 | — | — | EP | disclosed |