Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.76 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | RGS12 | O14924 | 1/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | PRKCG | P05129 | 1/20 | 0.56 |
| ▸ | PRKCB | P05771 | 1/20 | 0.56 |
| ▸ | PRKCA | P17252 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9413540 | 0.81 | EGFR (0.59) | BRAFMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL7072330 | 0.81 | BRAF (0.58) | BRAFMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL9413535 | 0.81 | EGFR (0.59) | BRAFMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL5080930 | 0.75 | HSD17B10 (0.65) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9413534 | 0.73 | MAPT (0.49) | BRAFMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL2459339 | 0.73 | ALDH1A1 (0.51) | BRAFMAPTALDH1A1KDM4EMEN1 | |
| Daph SCHEMBL11017 | 0.72 | EGFR (1.00) | BRAFMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL22923206 | 0.70 | MEN1 (0.67) | BRAFMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL8834218 | 0.69 | TDP1 (0.69) | BRAFMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL9381294 | 0.69 | APP (0.70) | BRAFMAPTALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600831-A1 | Phtalazinon derivatives | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | claimed |
| JP-6228108-A | — | — | None | — | — | JP | disclosed |
| JP-H06228108-A | PHTHALAZINONE DERIVATIVE | CIBA GEIGY AG | 1994-08-16 | — | — | JP | disclosed |
| EP-0600831-A1 | Phtalazinon derivatives | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | disclosed |