Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | BRAF | P15056 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
| ▸ | UBE2I | P63279 | 1/20 | 0.46 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.46 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9413535 | 0.81 | EGFR (0.59) | EGFRBRAFNPC1RAB9ACDC25B | |
| SCHEMBL9413538 | 0.81 | BRAF (0.76) | EGFRBRAFCDC25BUBE2ISAE1 | |
| SCHEMBL8834183 | 0.74 | EGFR (1.00) | EGFRBRAFNPC1RAB9AAPP | |
| SCHEMBL2244770 | 0.73 | RAPGEF4 (0.58) | EGFRNPC1RAB9AAPPLMNA | |
| SCHEMBL2462837 | 0.71 | KDM4E (0.55) | NPC1LMNAMAPTKDM4EMEN1 | |
| SCHEMBL30620470 | 0.71 | NPC1 (0.58) | EGFRNPC1RAB9AAPPLMNA | |
| SCHEMBL8834275 | 0.70 | EGFR (0.69) | EGFRNPC1RAB9ACDC25BAPP | |
| SCHEMBL17858219 | 0.70 | RAPGEF4 (0.61) | EGFRNPC1RAB9AL3MBTL1GAA | |
| SCHEMBL29555598 | 0.69 | HPGD (0.54) | EGFRNPC1RAB9ACDC25BUBE2I | |
| SCHEMBL12345617 | 0.69 | RAPGEF4 (0.58) | EGFRNPC1RAB9AAPPL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600831-A1 | Phtalazinon derivatives | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | claimed |
| EP-0600831-A1 | Phtalazinon derivatives | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | disclosed |