Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.35 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9414729 | 0.77 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10822561 | 0.71 | PTAFR (0.43) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL31298947 | 0.60 | WHR1 (0.33) | CYP1A2CYP3A4CYP2C9GAAKMT2A | |
| SCHEMBL2499173 | 0.59 | ALDH1A1 (0.58) | TLK2EGFRRETALDH1A1CA1 | |
| SCHEMBL28616279 | 0.59 | PDE3B (0.61) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL3292808 | 0.58 | CCNB2 (0.47) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL24221587 | 0.57 | RET (0.49) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL5489309 | 0.57 | KDM4E (0.47) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL31684818 | 0.56 | PTGS2 (0.35) | — | |
| SCHEMBL24472607 | 0.55 | RET (0.61) | CYP1A2CYP3A4CYP2C9TLK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594877-A1 | Imidazo(1,2-c)quinazoline derivates as antihyper tensives and anti dysurics | NATIONAL SCIENCE COUNCIL (TW) | 1994-05-04 | — | — | EP | disclosed |
| US-5158953-A | 2-substituted methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-ones (thiones), the preparation and use thereof | NATIONAL SCIENCE COUNCIL (TW) | 1992-10-27 | — | — | US | disclosed |