⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1275147 | 0.81 | NOS1 (0.42) | — | |
| SCHEMBL4083264 | 0.79 | NPC1 (0.48) | — | |
| SCHEMBL30102203 | 0.79 | KMT2A (0.64) | — | |
| SCHEMBL28651874 | 0.79 | KMT2A (0.64) | — | |
| SCHEMBL28651876 | 0.79 | KMT2A (0.64) | — | |
| SCHEMBL15432324 | 0.75 | — | — | |
| SCHEMBL1547811 | 0.75 | — | — | |
| SCHEMBL14257227 | 0.75 | — | — | |
| SCHEMBL115285 | 0.75 | NPC1 (0.46) | — | |
| SCHEMBL22964146 | 0.74 | MAOB (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102906091-A | Matrinic acid/matrine derivative and its preparation method and use | INST MED BIOTECHNOLOGY CAMS | 2013-01-30 | — | — | CN | claimed |
| US-4129740-A | Process for the preparation of para-nitroso-diphenylhydroxylamines | AKZONA INCORPORATED (US) | 1978-12-12 | — | — | US | claimed |
| CN-116693404-A | Novel method for preparing 4-diaryl methyl substituted tertiary aromatic amine compound by mediation of hexafluoroisopropanol | 湖南理工学院 | 2023-09-05 | — | — | CN | disclosed |
| WO-2023146989-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| US-10596183-B2 | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases | Zhejiang DTRM Biopharma Co. Ltd. (CN) | 2020-03-24 | — | — | US | disclosed |
| US-20190192541-A1 | Pharmaceutical Compositions and Their Use for Treatment of Cancer and Autoimmune Diseases | Zhejiang DTRM Biopharma Co. Ltd. (CN) | 2019-06-27 | — | — | US | disclosed |
| EP-2744030-B1 | NON-AQUEOUS ELECTROLYTE AND ELECTRICITY STORAGE DEVICE USING SAME | UBE INDUSTRIES (JP) | 2016-04-06 | — | — | EP | disclosed |
| EP-2744030-A1 | NON-AQUEOUS ELECTROLYTE AND ELECTRICITY STORAGE DEVICE USING SAME | UBE Industries, Ltd. (JP) | 2014-06-18 | — | — | EP | disclosed |
| US-8372985-B2 | Process of making α-aminooxyketone/α-aminooxyaldehyde and α-hydroxyketone/α-hydroxyaldehyde compounds and a process of making reaction products from cyclic α, β-unsaturated ketone substrates and nitroso substrates | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2013-02-12 | — | — | US | disclosed |
| US-20120302792-A1 | PROCESS OF MAKING ALPHA-AMINOOXYKETONE/ALPHA-AMINOOXYALDEHYDE AND ALPHA-HYDROXYKETONE/ALPHA-HYDROXYALDEHYDE COMPOUNDS AND A PROCESS MAKING REACTION PRODUCTS FROM CYCLIC ALPHA, BETA-UNSATURATED KETONE SUBSTRATES AND NITROSO SUBSTRATES | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2012-11-29 | — | — | US | disclosed |
| US-8318755-B2 | Inhibitors of SYK and JAK protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20080076924-A1 | Piperazines as P2X7 antagonists | ABBOTT LABORATORIES | 2008-03-27 | — | — | US | disclosed |
| US-20070055081-A1 | Processes for production of alpha-aminooxyketones and alpha-hydroxyketones | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2007-03-08 | — | — | US | disclosed |
| US-20070037973-A1 | reacting a cyclic alpha , beta -unsaturated ketone compound with a nitroso compound in the presence of a proline-based catalyst to provide 7-Phenyl-6-oxa-7-aza-bicyclo[3.2.2]nonan-9-one or derivatives; catalytic asymmetric O-nitroso Aldol/Michael reaction | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2007-02-15 | — | — | US | disclosed |
| EP-1717221-A1 | PROCESSES FOR PRODUCTION OF ALPHA-AMINOOXYKETONES AND ALPHA-HYDROXYKETONES | Japan Science and Technology Agency (JP) | 2006-11-02 | — | — | EP | disclosed |
| US-20040097570-A1 | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds | NEUROSEARCH A/S | 2004-05-20 | — | — | US | disclosed |
| EP-0009267-B1 | PROCESS FOR THE PREPARATION OF P-NITROSO-DIPHENYLHYDROXYLAMINES | AKZO N.V. (NL) | 1981-11-25 | — | — | EP | disclosed |
| US-4242523-A | Process for the preparation of para-nitroso-diphenyl-hydroxylamines | AKZONA INCORPORATED (US) | 1980-12-30 | — | — | US | disclosed |
| EP-0009267-A1 | Process for the preparation of p-nitroso-diphenylhydroxylamines | AKZO N.V. (NL) | 1980-04-02 | — | — | EP | disclosed |
| US-4129740-A | Process for the preparation of para-nitroso-diphenylhydroxylamines | AKZONA INCORPORATED (US) | 1978-12-12 | — | — | US | disclosed |