Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 16/20 | 0.54 |
| ▸ | MMP3 | P08254 | 4/20 | 0.54 |
| ▸ | MMP9 | P14780 | 2/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 3/20 | 0.50 |
| ▸ | ANPEP | P15144 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5552437 | 0.81 | MMP1 (0.54) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL28221966 | 0.80 | MMP1 (0.60) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL28221962 | 0.80 | MMP1 (0.60) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL28222036 | 0.80 | MMP1 (0.60) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL9832852 | 0.77 | MMP1 (0.56) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL9830801 | 0.76 | NPY5R (0.54) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL5558798 | 0.76 | MMP1 (0.74) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL1871252 | 0.75 | ANPEP (0.57) | MMP1MMP3MMP9ADAM17ANPEP | |
| SCHEMBL9502392 | 0.74 | MMP1 (0.41) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL10495976 | 0.74 | MMP1 (0.41) | MMP1MMP3MMP9ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229667-B1 | Peptidylaminodiols | ABBOTT LAB (US) | 1994-07-13 | — | — | EP | disclosed |
| US-5214129-A | Amidation of a protected amino acid by an di-O-protected dihydroxy-containing amine and coupling with a carboxylic acid; deprotecting; renin inhibitors; hypotensive agents | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | disclosed |
| US-5032577-A | Hypotensive | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| EP-0295294-A4 | PEPTIDYLAMINODIOLS. | ABBOTT LAB (US) | 1990-04-10 | — | — | EP | disclosed |
| US-4845079-A | HYPOTENSIVE, RENIN INHIBITION | ABBOTT LABORATORIES | 1989-07-04 | — | — | US | disclosed |
| EP-0295294-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-12-21 | — | — | EP | disclosed |
| WO-1988005050-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-07-14 | — | — | WO | disclosed |
| EP-0229667-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1987-07-22 | — | — | EP | disclosed |