Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.41 |
| ▸ | FCER2 | P06734 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.39 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 4/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.39 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7277904 | 0.86 | FCER2 (0.45) | RENFCER2MMP1GHSRCA12 | |
| SCHEMBL11759100 | 0.84 | REN (0.54) | RENFCER2MMP1CTSLERAP2 | |
| SCHEMBL11765581 | 0.84 | REN (0.54) | RENFCER2MMP1CTSLERAP2 | |
| SCHEMBL9472410 | 0.84 | REN (0.47) | RENFCER2MMP1CTSLERAP2 | |
| SCHEMBL9417261 | 0.83 | REN (0.48) | RENFCER2MMP1CTSLERAP2 | |
| Hydrochloric Acid SCHEMBL11764160 | 0.83 | REN (0.53) | RENFCER2MMP1CTSLERAP2 | |
| SCHEMBL9832615 | 0.82 | OPRM1 (0.40) | MMP1ITGA4ITGB7ERAP2LNPEP | |
| SCHEMBL10605598 | 0.81 | PTPN1 (0.52) | RENFCER2MMP1CTSLERAP2 | |
| SCHEMBL7271435 | 0.81 | CTSL (0.50) | RENFCER2MMP1CTSL | |
| SCHEMBL9417336 | 0.81 | REN (0.48) | RENFCER2MMP1GHSRCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229667-B1 | Peptidylaminodiols | ABBOTT LAB (US) | 1994-07-13 | — | — | EP | disclosed |
| US-5214129-A | Amidation of a protected amino acid by an di-O-protected dihydroxy-containing amine and coupling with a carboxylic acid; deprotecting; renin inhibitors; hypotensive agents | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | disclosed |
| US-5091575-A | Renin inhibitor | ABBOTT LABORATORIES (US) | 1992-02-25 | — | — | US | disclosed |
| US-5032577-A | Hypotensive | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| EP-0295294-A4 | PEPTIDYLAMINODIOLS. | ABBOTT LAB (US) | 1990-04-10 | — | — | EP | disclosed |
| US-4845079-A | HYPOTENSIVE, RENIN INHIBITION | ABBOTT LABORATORIES | 1989-07-04 | — | — | US | disclosed |
| EP-0295294-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-12-21 | — | — | EP | disclosed |
| WO-1988005050-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-07-14 | — | — | WO | disclosed |
| EP-0229667-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1987-07-22 | — | — | EP | disclosed |