Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417494 | 1.00 | PLA2G2A (0.50) | PLA2G2ABLMTSHRLMNAALDH1A1 | |
| SCHEMBL27472697 | 0.81 | LTA4H (0.42) | TSHRLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL11638360 | 0.81 | NPC1 (0.45) | TSHRLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL27576865 | 0.80 | ALDH1A1 (0.44) | TSHRLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL28170173 | 0.80 | NPC1 (0.42) | TSHRLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL27794045 | 0.80 | LTA4H (0.41) | TSHRLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL3352270 | 0.79 | LTA4H (0.43) | TSHRLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL6002725 | 0.78 | TSHR (0.49) | PLA2G2ABLMTSHRLMNAALDH1A1 | |
| SCHEMBL11598815 | 0.78 | LTA4H (0.40) | TSHRLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL31061150 | 0.78 | TSHR (0.49) | PLA2G2ABLMTSHRLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |