Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.49 |
| ▸ | CNR2 | P34972 | 6/20 | 0.39 |
| ▸ | CNR1 | P21554 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417949 | 0.89 | PPARA (0.42) | NR1H4L3MBTL1MAPK1ALDH1A1LMNA | |
| SCHEMBL9417928 | 0.88 | NR1H4 (0.44) | NR1H4CNR2CNR1L3MBTL1MAPK1 | |
| SCHEMBL9417782 | 0.85 | LTB4R (0.43) | NR1H4HTTTHRBL3MBTL1MAPK1 | |
| SCHEMBL9417846 | 0.85 | LTB4R (0.43) | NR1H4HTTTHRBL3MBTL1MAPK1 | |
| SCHEMBL9417879 | 0.85 | LTB4R (0.43) | NR1H4HTTTHRBL3MBTL1MAPK1 | |
| SCHEMBL9417852 | 0.85 | LTB4R (0.43) | NR1H4HTTTHRBL3MBTL1MAPK1 | |
| SCHEMBL9417929 | 0.85 | LTB4R (0.43) | NR1H4HTTTHRBL3MBTL1MAPK1 | |
| SCHEMBL9417877 | 0.84 | LTB4R (0.42) | NR1H4HTTTHRBL3MBTL1MAPK1 | |
| SCHEMBL9735495 | 0.82 | NR1H4 (0.48) | NR1H4THRBALDH1A1HPGD | |
| SCHEMBL9417953 | 0.82 | LTB4R (0.42) | NR1H4THRBL3MBTL1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294613-A | Benzene derivatives of p-substituted ether and acid or ester | ELI LILLY AND COMPANY (US) | 1994-03-15 | — | — | US | disclosed |
| US-5098613-A | Aromatic ethers for treatment of mammals | ELI LILLY AND COMPANY (US) | 1992-03-24 | — | — | US | disclosed |
| US-4945099-A | LEUKOTRIENE ANTAGONIST | ELI LILLY AND COMPANY (US) | 1990-07-31 | — | — | US | disclosed |
| EP-0276065-B1 | ANTI-INFLAMMATORY AGENTS | ELI LILLY AND COMPANY (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0276065-A1 | Anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1988-07-27 | — | — | EP | disclosed |