Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.48 |
| ▸ | PDE5A | O76074 | 6/20 | 0.45 |
| ▸ | PDE1A | P54750 | 2/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 10/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417917 | 0.99 | NR1H4 (0.47) | NR1H4PDE5APDE1APDE1BPDE1C | |
| SCHEMBL9417949 | 0.87 | PPARA (0.42) | NR1H4PDE5AALDH1A1TSHR | |
| SCHEMBL9417757 | 0.83 | LTB4R (0.53) | NR1H4PDE5ALTB4RLTB4R2MEN1 | |
| SCHEMBL9417971 | 0.82 | LTB4R (0.53) | NR1H4PDE5ALTB4RLTB4R2MEN1 | |
| SCHEMBL9417832 | 0.82 | NR1H4 (0.49) | NR1H4ALDH1A1THRBHPGD | |
| SCHEMBL9735490 | 0.81 | TSHR (0.37) | LTB4RLTB4R2TSHR | |
| SCHEMBL9417958 | 0.80 | NR1H4 (0.56) | NR1H4PDE5ALTB4RLTB4R2ALDH1A1 | |
| SCHEMBL9417862 | 0.79 | PDE5A (0.60) | NR1H4PDE5APDE1APDE1BPDE1C | |
| SCHEMBL9417905 | 0.79 | NR1H4 (0.48) | NR1H4LTB4RLTB4R2ALDH1A1HPGD | |
| SCHEMBL9417940 | 0.78 | LTB4R (0.51) | NR1H4LTB4RLTB4R2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098613-A | Aromatic ethers for treatment of mammals | ELI LILLY AND COMPANY (US) | 1992-03-24 | — | — | US | disclosed |
| US-4945099-A | LEUKOTRIENE ANTAGONIST | ELI LILLY AND COMPANY (US) | 1990-07-31 | — | — | US | disclosed |
| EP-0276065-B1 | ANTI-INFLAMMATORY AGENTS | ELI LILLY AND COMPANY (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0276065-A1 | Anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1988-07-27 | — | — | EP | disclosed |