Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.48 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 4/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739697 | 0.88 | NPC1 (0.56) | THRAMTNR1BNPC1RAB9AMTNR1A | |
| SCHEMBL2422646 | 0.85 | LTB4R (0.45) | THRALTB4RPPARGPPARDPPARA | |
| SCHEMBL10522356 | 0.85 | LTB4R (0.56) | THRALTB4RTHRB | |
| SCHEMBL6935194 | 0.84 | LTB4R (0.46) | THRALTB4RPPARGPPARDPPARA | |
| SCHEMBL6136991 | 0.84 | LTB4R (0.44) | THRALTB4RPPARGPPARDPPARA | |
| SCHEMBL8777238 | 0.84 | LTB4R (0.44) | THRALTB4RPPARGPPARDPPARA | |
| SCHEMBL9387348 | 0.82 | LTB4R (0.48) | THRALTB4RTHRB | |
| SCHEMBL6934988 | 0.82 | LTB4R (0.42) | THRALTB4RPPARGPPARDPPARA | |
| Hydrochloric Acid SCHEMBL9417918 | 0.81 | LTB4R (0.45) | THRALTB4RPPARGPPARDPPARA | |
| SCHEMBL5711634 | 0.80 | LTB4R (0.53) | THRALTB4RTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294613-A | Benzene derivatives of p-substituted ether and acid or ester | ELI LILLY AND COMPANY (US) | 1994-03-15 | — | — | US | disclosed |
| US-5098613-A | Aromatic ethers for treatment of mammals | ELI LILLY AND COMPANY (US) | 1992-03-24 | — | — | US | disclosed |
| US-4945099-A | LEUKOTRIENE ANTAGONIST | ELI LILLY AND COMPANY (US) | 1990-07-31 | — | — | US | disclosed |
| EP-0276065-B1 | ANTI-INFLAMMATORY AGENTS | ELI LILLY AND COMPANY (US) | 1990-06-06 | — | — | EP | disclosed |