Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.48 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10808351 | 0.89 | NPC1 (0.55) | NPC1HPGDRAB9ASMN1; SMN2PTGER1 | |
| SCHEMBL542660 | 0.88 | PTGER1 (0.56) | NPC1HPGDRAB9ASMN1; SMN2PTGER1 | |
| SCHEMBL9417841 | 0.88 | THRA (0.52) | NPC1RAB9AMTNR1AMTNR1BTHRA | |
| SCHEMBL15338464 | 0.87 | MAOB (0.55) | NPC1HPGDRAB9ASMN1; SMN2PTGER1 | |
| SCHEMBL541510 | 0.85 | HPGD (0.54) | NPC1HPGDRAB9ASMN1; SMN2PTGER1 | |
| SCHEMBL10735687 | 0.82 | SMN1; SMN2 (0.70) | NPC1HPGDRAB9ASMN1; SMN2PTGER1 | |
| SCHEMBL7319710 | 0.81 | FFAR4 (0.59) | NPC1HPGDRAB9ASMN1; SMN2EGFR | |
| SCHEMBL9417828 | 0.81 | NPC1 (0.49) | NPC1HPGDRAB9ASMN1; SMN2PTGER1 | |
| SCHEMBL1400284 | 0.81 | NPC1 (0.45) | NPC1HPGDRAB9ASMN1; SMN2PTGER1 | |
| SCHEMBL10676508 | 0.81 | PTGER1 (0.61) | NPC1HPGDRAB9ASMN1; SMN2PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |
| EP-0165810-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES, THEIR USE IN INHIBITING MAMMALIAN LEUKOTRIENE BIOSYNTHESIS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES | MERCK FROSST CANADA INC. (CA) | 1989-08-23 | — | — | EP | disclosed |
| EP-0165810-A2 | Benzofuran and benzothiophene derivatives, their use in inhibiting mammalian leukotriene biosynthesis, and pharmaceutical compositions containing these derivatives | MERCK FROSST CANADA INC. (CA) | 1985-12-27 | — | — | EP | disclosed |
| EP-0017332-B1 | PHARMACEUTICAL HETEROCYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | FISONS plc (GB) | 1985-07-31 | — | — | EP | disclosed |
| US-4281008-A | Pharmaceutical heterocyclic compounds and compositions | FISONS LIMITED (GB) | 1981-07-28 | — | — | US | disclosed |
| EP-0017332-A1 | Pharmaceutical heterocyclic compounds, processes for their preparation and compositions containing them | FISONS plc (GB) | 1980-10-15 | — | — | EP | disclosed |