Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 5/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9419023 | 0.88 | TDP2 (0.42) | CMA1AHRTDP2TDP1L3MBTL1 | |
| SCHEMBL7796330 | 0.84 | CMA1 (0.47) | CMA1AHRTDP2TDP1L3MBTL1 | |
| SCHEMBL9418964 | 0.80 | CMA1 (0.42) | CMA1AHRTDP2L3MBTL1BRD4 | |
| SCHEMBL8370875 | 0.76 | TDP2 (0.47) | CMA1AHRTDP2TDP1L3MBTL1 | |
| SCHEMBL1706762 | 0.76 | KDM1A (0.53) | CMA1AHRTDP2TDP1L3MBTL1 | |
| SCHEMBL29804270 | 0.76 | KDM1A (0.53) | CMA1AHRTDP2TDP1L3MBTL1 | |
| SCHEMBL2012588 | 0.73 | BACE1 (0.51) | CMA1AHRKDM1ABACE1APP | |
| SCHEMBL3361527 | 0.71 | PGR (0.55) | CMA1AHRTDP2PDE4BMETAP1 | |
| SCHEMBL6674280 | 0.71 | BACE1 (0.47) | KDM1ABACE1APP | |
| SCHEMBL10182282 | 0.71 | TDP1 (0.48) | CMA1AHRTDP2TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315071-B1 | Benzocyclohepten derivatives, their preparation and utilisation for pharmaceutics | HOFFMANN LA ROCHE (CH) | 1994-07-20 | — | — | EP | disclosed |
| US-4992574-A | Skin disorders, antiallergens, antiinflammatory agent | HOFFMANN-LA ROCHE INC. (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0315071-A2 | Benzocyclohepten derivatives, their preparation and utilisation for pharmaceutics | F. HOFFMANN-LA ROCHE AG (CH) | 1989-05-10 | — | — | EP | disclosed |