Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | TDP2 | O95551 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8370875 | 0.88 | TDP2 (0.47) | CMA1AHRTDP2BRD4METAP1 | |
| SCHEMBL9418949 | 0.84 | CMA1 (0.42) | CMA1AHRTDP2BRD4METAP1 | |
| SCHEMBL9418964 | 0.81 | CMA1 (0.42) | CMA1AHRTDP2BRD4METAP1 | |
| SCHEMBL28103402 | 0.77 | CMA1 (0.42) | CMA1AHRTDP2BRD4METAP1 | |
| SCHEMBL7154577 | 0.76 | METAP1 (0.45) | TDP2METAP1ALDH1A1 | |
| SCHEMBL9419023 | 0.76 | TDP2 (0.42) | CMA1AHRTDP2BRD4METAP1 | |
| SCHEMBL1871781 | 0.76 | HTR2A (0.50) | AHRTDP2ALDH1A1 | |
| SCHEMBL17808124 | 0.73 | CMA1 (0.44) | CMA1AHRTDP2BRD4METAP1 | |
| SCHEMBL3361527 | 0.73 | PGR (0.55) | CMA1AHRTDP2METAP1PDE4B | |
| SCHEMBL9418969 | 0.72 | CMA1 (0.35) | CMA1AHRTDP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591583-B1 | Benzo (f) quinolinones as 5-alpha-reductase inhibitors | LILLY CO ELI (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0532190-B1 | Benzo(f)quinolinones as 5-alpha-reductase inhibitors | LILLY CO ELI (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-0591582-B1 | Hexahydrobenzo (f) quinolinones as 5-alpha-reductase inhibitors | LILLY CO ELI (US) | 1999-01-20 | — | — | EP | disclosed |
| EP-0531026-B1 | Hexahydrobenzo[f]quinolinones as 5-alpha-reductase inhibitors | LILLY CO ELI (US) | 1998-11-18 | — | — | EP | disclosed |
| CN-1039320-C | Process for preparing hexahydro-and octahydro-benzo [ f ] quinolinones and optical isomers thereof | LILLY CO ELI (US) | 1998-07-29 | — | — | CN | disclosed |
| US-5710163-A | STEROID 5A-REDUCTASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-01-20 | — | — | US | disclosed |
| US-5670512-A | SKIN DISORDERS; REDUCTASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-09-23 | — | — | US | disclosed |
| US-5541190-A | TREATING BENIGN PROSTATIC HYPERPLASIA, MALE PATTERN BALDNESS, PROSTATIC CANCER, ANDROGENIC ALOPECIA | ELI LILLY AND COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| US-5495021-A | STEROID 5 ALPHA-REDUCTASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-27 | — | — | US | disclosed |
| US-5334767-A | Steroid 5a-reductase inhibitor | ELI LILLY AND COMPANY (US) | 1994-08-02 | — | — | US | disclosed |
| EP-0591583-A1 | Benzo (f) quinolinones as 5-alpha-reductase inhibitors | ELI LILLY AND COMPANY (US) | 1994-04-13 | — | — | EP | disclosed |
| EP-0591582-A1 | Hexahydrobenzo (f) quinolinones as 5-alpha-reductase inhibitors | ELI LILLY AND COMPANY (US) | 1994-04-13 | — | — | EP | disclosed |
| US-5250539-A | 5-alpha reductase inhibitors; administer as therapy for benign prostatic hyperplasia, hirsutism and acne | ELI LILLY AND COMPANY (US) | 1993-10-05 | — | — | US | disclosed |
| US-5239075-A | PROCESS FOR THE PREPARATION OF BENZO (F) QUINOLINONES | ELI LILLY AND COMPANY (US) | 1993-08-24 | — | — | US | disclosed |
| CN-1071418-A | Benzo [ f ] quinolinones | LILLY CO ELI (US) | 1993-04-28 | — | — | CN | disclosed |
| EP-0532190-A2 | Benzo f quinolinones as 5-alpha-reductase inhibitors | ELI LILLY AND COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0531026-A1 | Hexahydrobenzo[f]quinolinones as 5-alpha-reductase inhibitors | ELI LILLY AND COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |
| CN-1069488-A | Hexahydrobenzene is [f] quinolinone also | LILLY CO ELI (US) | 1993-03-03 | — | — | CN | disclosed |