⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29061272 | 0.73 | — | — | |
| SCHEMBL28609350 | 0.71 | — | — | |
| SCHEMBL28611936 | 0.71 | — | — | |
| SCHEMBL28486940 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL28486687 | 0.68 | MEN1 (0.46) | — | |
| SCHEMBL3311774 | 0.68 | — | — | |
| SCHEMBL724694 | 0.68 | — | — | |
| SCHEMBL5094113 | 0.67 | — | — | |
| SCHEMBL19755650 | 0.67 | ALDH1A1 (0.62) | — | |
| SCHEMBL18672829 | 0.67 | MEN1 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108774214-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-105121432-B | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2018-08-03 | — | — | CN | disclosed |
| CN-106928203-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2017-07-07 | — | — | CN | disclosed |
| CN-101153027-B | Process for the manufacture of valsartan | NOVARTIS AG | 2010-08-18 | — | — | CN | disclosed |
| CN-101153027-A | Process for the manufacture of valsartan | NOVARTIS AG (CH) | 2008-04-02 | — | — | CN | disclosed |
| CN-100357279-C | Process for preparing valsartan | NOVARTIS AG (CH) | 2007-12-26 | — | — | CN | disclosed |
| CN-1688556-A | Process for preparing valsartan | NOVARTIS AG (CH) | 2005-10-26 | — | — | CN | disclosed |
| US-5332820-A | Diuretic, hypotensive agent, treating congestive heart failure | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-07-26 | — | — | US | disclosed |