Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.39 |
| ▸ | ZDHHC20 | Q5W0Z9 | 2/20 | 0.33 |
| ▸ | ZDHHC2 | Q9UIJ5 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ADH1C | P00326 | 1/20 | 0.31 |
| ▸ | ADH1A | P07327 | 1/20 | 0.31 |
| ▸ | ADH4 | P08319 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2364576 | 0.89 | FAAH (0.39) | FAAHTSHRALDH1A1DNM1ZDHHC20 | |
| SCHEMBL11617998 | 0.85 | TSHR (0.35) | FAAHTSHRALDH1A1 | |
| SCHEMBL3674964 | 0.79 | — | — | |
| SCHEMBL7688797 | 0.77 | FAAH (0.41) | FAAHTSHRALDH1A1DNM1ZDHHC20 | |
| SCHEMBL5365307 | 0.76 | FAAH (0.36) | FAAHTSHRALDH1A1DNM1ADH1C | |
| SCHEMBL7688794 | 0.76 | FAAH (0.40) | FAAHTSHRALDH1A1DNM1ZDHHC20 | |
| SCHEMBL5823693 | 0.74 | TSHR (0.37) | FAAHTSHRALDH1A1DNM1ZDHHC20 | |
| SCHEMBL9421760 | 0.74 | DNM1 (0.46) | TSHRALDH1A1DNM1THRBCA12 | |
| SCHEMBL695561 | 0.73 | FAAH (0.45) | FAAHTSHRALDH1A1ZDHHC20ZDHHC2 | |
| SCHEMBL2361409 | 0.72 | DNM1 (0.43) | TSHRALDH1A1DNM1THRBADH1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5300500-A | 4 beta-amino podophyllotoxin analog compounds and methods | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1994-04-05 | — | — | US | disclosed |
| WO-1993022319-A1 | 4-BETA-AMINO PODOPHYLLOTOXIN DERIVATIVES ANTITUMOR AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1993-11-11 | — | — | WO | disclosed |