Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A2 | Q05940 | 5/20 | 0.58 |
| ▸ | HTR2A | P28223 | 3/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.58 |
| ▸ | DRD4 | P21917 | 2/20 | 0.58 |
| ▸ | HTR1B | P28222 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7322255 | 0.82 | ACHE (0.64) | SLC18A2HTR2ASLC6A3HTR1ADRD4 | |
| SCHEMBL17474575 | 0.79 | SLC18A2 (0.72) | SLC18A2HTR2ASLC6A3HTR1ADRD4 | |
| SCHEMBL11013197 | 0.79 | DRD2 (0.61) | SLC18A2HTR2ASLC6A3HTR1ADRD4 | |
| SCHEMBL9872201 | 0.76 | SLC18A2 (0.68) | SLC18A2HTR2ASLC6A3HTR1ADRD4 | |
| SCHEMBL10691634 | 0.75 | CYP3A4 (0.68) | SLC18A2HTR2ASLC6A3HTR1ADRD4 | |
| SCHEMBL11013116 | 0.74 | HTR2A (0.73) | SLC18A2HTR2ASLC6A3HTR1ADRD4 | |
| SCHEMBL9092322 | 0.74 | DRD2 (0.47) | HTR2AKCNH2DRD2SLC6A4HTR7 | |
| SCHEMBL7285993 | 0.73 | ACHE (0.62) | HTR2AHTR1AHTR2CALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL7318328 | 0.73 | DRD2 (0.53) | SLC18A2HTR2ASLC6A3HTR1ADRD4 | |
| Ketanserin SCHEMBL34294 | 0.73 | HTR2A (1.00) | SLC18A2HTR2ASLC6A3HTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5321028-A | Antihypertensive 3-piperidinyl-indazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-06-14 | — | — | US | disclosed |
| US-5196425-A | Antihypertensive 3-piperidinyl-indazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-23 | — | — | US | disclosed |