Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9424379 | 0.82 | SMN1; SMN2 (0.40) | ALDH1A1LMNAKDM4ESMN1; SMN2TSHR | |
| SCHEMBL13190055 | 0.82 | ALDH1A1 (0.62) | ALDH1A1LMNAKDM4ESMN1; SMN2TSHR | |
| SCHEMBL9423830 | 0.79 | ALDH1A1 (0.44) | ALDH1A1LMNASMN1; SMN2L3MBTL1GAA | |
| SCHEMBL9424384 | 0.79 | AKR1C3 (0.48) | LMNASMN1; SMN2TSHRL3MBTL1NPSR1 | |
| SCHEMBL9424280 | 0.77 | ALDH1A1 (0.44) | ALDH1A1LMNAKDM4ESMN1; SMN2TSHR | |
| SCHEMBL10104444 | 0.75 | ALDH1A1 (0.69) | ALDH1A1LMNAKDM4ESMN1; SMN2TSHR | |
| SCHEMBL9423950 | 0.75 | LMNA (0.43) | ALDH1A1LMNAKDM4EL3MBTL1NPSR1 | |
| SCHEMBL330446 | 0.74 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4ESMN1; SMN2TSHR | |
| SCHEMBL31210318 | 0.74 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4ESMN1; SMN2TSHR | |
| SCHEMBL9060037 | 0.74 | ALDH1A1 (0.55) | ALDH1A1LMNAKDM4ESMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373008-A | Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents | THE BOOTS COMPANT PLC. (GB) | 1994-12-13 | — | — | US | disclosed |
| US-5223498-A | Hypoglycemic agents | THE BOOTS COMPANY PLC (GB) | 1993-06-29 | — | — | US | disclosed |
| EP-0385038-B1 | ORTHO-SUBSTITUTED PHENYL AMIDINE AND PHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | The Boots Company PLC (GB) | 1993-06-02 | — | — | EP | disclosed |
| EP-0385038-A1 | Ortho-substituted phenyl amidine and phenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them | The Boots Company PLC (GB) | 1990-09-05 | — | — | EP | disclosed |