Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 5/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9423995 | 1.00 | TSHR (0.39) | TSHRBRPF1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9423867 | 0.87 | SIGMAR1 (0.39) | TSHRALDH1A1NPC1MEN1KMT2A | |
| SCHEMBL9423865 | 0.87 | SIGMAR1 (0.39) | TSHRALDH1A1NPC1MEN1KMT2A | |
| SCHEMBL9059748 | 0.84 | GAA (0.36) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL9059752 | 0.84 | GAA (0.36) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL9423979 | 0.81 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL9423977 | 0.81 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL9059425 | 0.80 | NPC1 (0.36) | ALDH1A1SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL9059423 | 0.80 | NPC1 (0.36) | ALDH1A1SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL9424297 | 0.80 | ALDH1A1 (0.40) | TSHRALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373008-A | Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents | THE BOOTS COMPANT PLC. (GB) | 1994-12-13 | — | — | US | disclosed |
| US-5223498-A | Hypoglycemic agents | THE BOOTS COMPANY PLC (GB) | 1993-06-29 | — | — | US | disclosed |
| EP-0385038-B1 | ORTHO-SUBSTITUTED PHENYL AMIDINE AND PHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | The Boots Company PLC (GB) | 1993-06-02 | — | — | EP | disclosed |
| EP-0385038-A1 | Ortho-substituted phenyl amidine and phenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them | The Boots Company PLC (GB) | 1990-09-05 | — | — | EP | disclosed |