Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.45 |
| ▸ | MEN1 | O00255 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9424731 | 0.83 | ALDH1A1 (0.51) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL9424721 | 0.82 | MAPT (0.58) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL9424478 | 0.80 | KMT2A (0.48) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL9424446 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL9424464 | 0.79 | KMT2A (0.47) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL9424517 | 0.77 | KMT2A (0.47) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL9424704 | 0.77 | ALDH1A1 (0.44) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL9424273 | 0.75 | IDH1 (0.49) | ALDH1A1SMN1; SMN2RAB9AIDH1CA12 | |
| SCHEMBL5966521 | 0.75 | FLT1 (0.61) | — | |
| SCHEMBL9424582 | 0.75 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5302724-A | Thiophenesulfonylureas; anticarcinogenic agents | ELI LILLY AND COMPANY (US) | 1994-04-12 | — | — | US | claimed |
| EP-0467613-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1992-01-22 | — | — | EP | claimed |
| US-5302724-A | Thiophenesulfonylureas; anticarcinogenic agents | ELI LILLY AND COMPANY (US) | 1994-04-12 | — | — | US | disclosed |
| EP-0467613-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1992-01-22 | — | — | EP | disclosed |