Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9424478 | 0.99 | KMT2A (0.48) | KMT2AMEN1KLKB1CTSBELANE | |
| SCHEMBL9424704 | 0.90 | ALDH1A1 (0.44) | KMT2AMEN1KLKB1CTSBELANE | |
| SCHEMBL9424699 | 0.87 | EPHX1 (0.48) | KMT2AMEN1ALDH1A1POLBRAB9A | |
| SCHEMBL9424554 | 0.85 | EPHX1 (0.49) | KMT2AMEN1ALDH1A1POLBRAB9A | |
| SCHEMBL9424703 | 0.84 | EPHX1 (0.48) | KMT2AMEN1ALDH1A1POLBHTT | |
| SCHEMBL9424731 | 0.82 | ALDH1A1 (0.51) | KMT2AMEN1ALDH1A1POLBRAB9A | |
| SCHEMBL9424721 | 0.81 | MAPT (0.58) | KMT2AMEN1ALDH1A1POLBHTT | |
| SCHEMBL9424517 | 0.81 | KMT2A (0.47) | KMT2AMEN1KLKB1CTSBELANE | |
| SCHEMBL9424401 | 0.80 | FBP1 (0.53) | KMT2AMEN1KLKB1CTSBELANE | |
| SCHEMBL9424582 | 0.79 | ALDH1A1 (0.43) | KMT2AMEN1KLKB1CTSBELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5302724-A | Thiophenesulfonylureas; anticarcinogenic agents | ELI LILLY AND COMPANY (US) | 1994-04-12 | — | — | US | disclosed |
| CN-1058401-A | Anti-tumor compositions and methods of treatment | LILLY CO ELI (US) | 1992-02-05 | — | — | CN | disclosed |
| EP-0467613-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1992-01-22 | — | — | EP | disclosed |