Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17359582 | 0.87 | ALDH1A1 (0.42) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9321255 | 0.81 | LMNA (0.51) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9318828 | 0.78 | KDM4E (0.65) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL14845162 | 0.76 | KDM4E (0.57) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9453128 | 0.76 | ALDH1A1 (0.36) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9319323 | 0.75 | ALDH1A1 (0.46) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6313804 | 0.75 | LMNA (0.62) | LMNAKDM4EALDH1A1 | |
| SCHEMBL9318038 | 0.74 | KMT2A (0.52) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9320881 | 0.73 | ALDH1A1 (0.50) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11752291 | 0.73 | KDM4E (0.47) | LMNAKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5318963-A | Heterocyclic hydrazide derivatives of monocyclic β-lactam antibiotics | E. R. SQUIBB & SONS, INC. (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0420069-A2 | Heterocyclic hydrazide derivatives of monocyclic beta-lactam antibiotics | E.R. SQUIBB & SONS, INC. (US) | 1991-04-03 | — | — | EP | disclosed |