Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.56 |
| ▸ | CXCR1 | P25024 | 4/20 | 0.56 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | SLC22A6 | Q4U2R8 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.56 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27761875 | 0.87 | PTGS1 (0.41) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL3674499 | 0.86 | PTGS2 (0.69) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL10276277 | 0.84 | PTGS2 (0.54) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL2319534 | 0.84 | PTGS2 (0.58) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL29393183 | 0.84 | PTGS2 (0.64) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL2391075 | 0.84 | PTGS2 (0.54) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL6903957 | 0.84 | PTGS2 (0.58) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL3242802 | 0.84 | PTGS2 (0.54) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL66533 | 0.84 | PTGS2 (0.64) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL66534 | 0.84 | PTGS2 (0.64) | PTGS2PTGS1CXCR1CXCR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5280034-A | Bis-heterocyclic prostaglandin analogs | E. R. SQUIBB & SONS, INC. (US) | 1994-01-18 | — | — | US | disclosed |
| US-4175202-A | 4,5,6-Trinor-3,7,-inter-m-phenylene prostaglandin A1 analogs | THE UPJOHN COMPANY (US) | 1979-11-20 | — | — | US | disclosed |
| US-4084058-A | HYPOTENSIVES, ANTICOAGULANTS | THE UPJOHN COMPANY (US) | 1978-04-11 | — | — | US | disclosed |
| US-4053485-A | OPTICALLY ACTIVE OR RACEMIC MIXTURES | THE UPJOHN COMPANY (US) | 1977-10-11 | — | — | US | disclosed |
| US-4032560-A | OXA PHENYLENE PROSTAGLANDIN ANALOGS | THE UPJOHN COMPANY (US) | 1977-06-28 | — | — | US | disclosed |
| US-4020097-A | HYPOTENSIVE, ANTICOAGULANT | THE UPJOHN COMPANY (US) | 1977-04-26 | — | — | US | disclosed |
| US-3997566-A | Tricyclic prostaglandin | THE UPJOHN COMPANY (US) | 1976-12-14 | — | — | US | disclosed |