Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683503 | 0.86 | APP (0.62) | RAF1MAP2K1APPKDM4EPOLB | |
| SCHEMBL9425740 | 0.81 | CDK8 (0.50) | HDAC1HDAC2APPKDM4ECDK8 | |
| SCHEMBL9426849 | 0.80 | HDAC1 (0.57) | HDAC1HDAC2TDP1 | |
| SCHEMBL9426326 | 0.79 | CDK8 (0.68) | APPNPC1RAB9ACDK8CLK4 | |
| SCHEMBL9426210 | 0.78 | CDK8 (0.47) | APPKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL9425845 | 0.74 | CYP3A4 (0.64) | CDK8CLK4 | |
| SCHEMBL5606608 | 0.74 | ALOX15 (0.61) | HDAC1HDAC2KDM4EALDH1A1NPC1 | |
| SCHEMBL12040759 | 0.72 | KMT2A (0.66) | KDM4EALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL9425410 | 0.72 | HDAC1 (0.49) | HDAC1HDAC2APPKDM4EALDH1A1 | |
| SCHEMBL19199578 | 0.71 | HDAC1 (0.49) | HDAC1HDAC2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5338745-A | Alzheimer's disease | MITSUI TOATSU CHEMICALS, INCORPORATION (JP) | 1994-08-16 | — | — | US | disclosed |
| EP-0495998-A1 | DIHYDROCAFFEIC ACID AMIDE DERIVATIVE AND APPLICATION THEREOF AS MEDICINE | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1992-07-29 | — | — | EP | disclosed |