Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.62 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.49 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9425903 | 0.86 | RAF1 (0.51) | APPPOLBKDM4ECDK8CLK4 | |
| SCHEMBL9425740 | 0.86 | CDK8 (0.50) | APPTHRBLTB4RLTB4R2KDM4E | |
| SCHEMBL19194094 | 0.84 | APP (0.68) | APPFFAR4MTNR1AMTNR1BPOLB | |
| SCHEMBL9426210 | 0.82 | CDK8 (0.47) | APPKDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL12040759 | 0.81 | KMT2A (0.66) | THRBLTB4R2KDM4EMEN1KMT2A | |
| SCHEMBL9426326 | 0.81 | CDK8 (0.68) | APPCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10826296 | 0.80 | CYP1A2 (0.59) | APPFFAR4MTNR1AMTNR1BPOLB | |
| SCHEMBL6582446 | 0.79 | FFAR4 (0.71) | APPFFAR4POLBMAPTTHRB | |
| SCHEMBL11827307 | 0.78 | FFAR4 (0.64) | APPFFAR4MTNR1AMTNR1BPOLB | |
| SCHEMBL5336051 | 0.77 | FFAR1 (0.76) | APPFFAR4THRBFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0495998-A1 | DIHYDROCAFFEIC ACID AMIDE DERIVATIVE AND APPLICATION THEREOF AS MEDICINE | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1992-07-29 | — | — | EP | disclosed |