Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | TOP2A | P11388 | 2/20 | 0.52 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 3/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALPI | P09923 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.49 |
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6157123 | 0.84 | MAPT (0.56) | MAPTTOP2ATOP2BBRD4MMP13 | |
| SCHEMBL29965486 | 0.82 | TOP2A (0.58) | MAPTTOP2ATOP2BBRD4PARP1 | |
| SCHEMBL4936991 | 0.82 | TOP2A (0.58) | MAPTTOP2ATOP2BBRD4PARP1 | |
| SCHEMBL4930061 | 0.81 | MMP13 (0.65) | MMP13TNKS2PKMTNKS | |
| SCHEMBL941961 | 0.79 | QTRT1 (0.59) | MAPTTOP2ATOP2BBRD4PARP1 | |
| SCHEMBL28060714 | 0.79 | BRD4 (0.59) | MAPTTOP2ATOP2BBRD4PARP1 | |
| SCHEMBL4935373 | 0.78 | MMP13 (0.57) | MAPTMMP13TNKS2ALDH1A1RAB9A | |
| SCHEMBL27334538 | 0.78 | BRD4 (0.74) | MAPTTOP2ATOP2BBRD4PARP1 | |
| SCHEMBL8187460 | 0.77 | TOP2A (0.59) | MAPTTOP2ATOP2BBRD4PARP1 | |
| SCHEMBL4936756 | 0.76 | MMP13 (0.62) | MAPTMMP13TNKS2TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009435-A1 | HETERO BICYCLIC CARBOXAMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER, INC. (US) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009435-A1 | HETERO BICYCLIC CARBOXAMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | CNR2, CYP2C9, CYP2C8 | MAPT 2878/4885TOP2A 3326/4885TOP2B 3059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.