SCHEMBL9427403

SCHEMBL9427403

CC(C)(C)c1ccc(CNC(N)=S)cc1

nearest known ligand 0.68

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 6/20 0.59
NR1H4 Q96RI1 4/20 0.59
TRPV1 Q8NER1 1/20 0.54
HDAC3 O15379 1/20 0.53
HDAC8 Q9BY41 1/20 0.53
HDAC6 Q9UBN7 1/20 0.53
MEN1 O00255 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2C19 P33261 1/20 0.51
KMT2A Q03164 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4881597 0.85 EPHX2 (0.60) EPHX2NR1H4TRPV1HDAC3HDAC8
SCHEMBL12049562 0.82 TRPV1 (0.63) TRPV1
SCHEMBL3428043 0.81 ALDH1A1 (0.54) HDAC3HDAC8HDAC6MEN1KMT2A
SCHEMBL11954 0.81 EPHX2 (0.59) EPHX2NR1H4HDAC3HDAC8HDAC6
SCHEMBL2827305 0.81 EPHX2 (0.69) EPHX2NR1H4HDAC3HDAC8HDAC6
SCHEMBL4891340 0.81 EPHX2 (0.68) EPHX2TRPV1
SCHEMBL9427574 0.80 TRPV1 (0.60) EPHX2NR1H4TRPV1
SCHEMBL12049322 0.79 TRPV1 (0.62) TRPV1
SCHEMBL12060793 0.79 TRPV1 (0.62) TRPV1
SCHEMBL12049334 0.79 ALOX12 (0.72) TRPV1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5281625-A Benzyl substituted guanidine derivatives, salts, and metal complexes BASF AKTIENGESELLSCHAFT (DE) 1994-01-25 US disclosed
US-5126374-A For plants, seeds, soils, effective at low concentrations BASF AKTIENGESELLSCHAFT (DE) 1992-06-30 US disclosed