Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 9/20 | 0.50 |
| ▸ | RXRA | P19793 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 2/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10797572 | 0.96 | PPARD (0.45) | NR4A2RXRAKDM4ETDP1HTT | |
| SCHEMBL1534075 | 0.89 | NR4A2 (0.59) | NR4A2RXRAKDM4EHPGDLMNA | |
| SCHEMBL9428091 | 0.86 | NR4A2 (0.53) | NR4A2RXRAKDM4EHPGDLMNA | |
| SCHEMBL6000535 | 0.81 | PTGS2 (0.63) | NR4A2RXRAKDM4ELMNAALDH1A1 | |
| SCHEMBL5823861 | 0.81 | PTGS2 (0.50) | NR4A2RXRALMNA | |
| SCHEMBL6002469 | 0.81 | PTGS2 (0.50) | NR4A2RXRALMNA | |
| SCHEMBL9427672 | 0.81 | ADAMTS4 (0.50) | NR4A2RXRAPPARDMMP13PPARG | |
| SCHEMBL6538884 | 0.80 | AKR1C3 (0.47) | NR4A2RXRAKDM4ETDP1HTT | |
| SCHEMBL13352330 | 0.80 | CYP11B1 (0.42) | KDM4ETDP1HTTMAPTHPGD | |
| SCHEMBL11752449 | 0.80 | TP53 (0.59) | NR4A2RXRAKDM4ETDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5364944-A | Antiinflammatory, antiallergic and cytoprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-11-15 | — | — | US | disclosed |
| US-5218124-A | Antiinflammatory agents, antiallergens and cytoprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-06-08 | — | — | US | disclosed |
| EP-0497888-A1 | SUBSTITUTED BENZOYLBENZENE-, BIPHENYL- AND 2-OXAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA 2? AND LIPOXYGENASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-08-12 | — | — | EP | disclosed |
| US-5071988-A | Antiu lcer agents, antiallergens cytoprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-10 | — | — | US | disclosed |
| WO-1991006538-A1 | SUBSTITUTED BENZOYLBENZENE-, BIPHENYL- AND 2-OXAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA2 AND LIPOXYGENASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-16 | — | — | WO | disclosed |