Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.44 |
| ▸ | HTR1A | P08908 | 7/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.44 |
| ▸ | HRH1 | P35367 | 3/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9428336 | 0.88 | HRH1 (0.48) | DRD2HTR1ADRD3ADRA1AHRH1 | |
| SCHEMBL9428349 | 0.85 | MEN1 (0.41) | DRD2HTR1ADRD3ADRA1AHRH1 | |
| SCHEMBL9429100 | 0.85 | HRH1 (0.49) | DRD2HTR1ADRD3ADRA1AHRH1 | |
| SCHEMBL9428300 | 0.85 | DPP4 (0.43) | DRD2HTR1ADRD3ADRA1AHRH1 | |
| SCHEMBL9428800 | 0.85 | HRH1 (0.46) | DRD2HTR1ADRD3ADRA1AHRH1 | |
| SCHEMBL9428373 | 0.84 | DRD2 (0.58) | DRD2HTR1ADRD3HRH1ADRA2C | |
| SCHEMBL9384567 | 0.84 | HTR1A (0.45) | HTR1AHRH1HRH2MAPTLMNA | |
| SCHEMBL9429282 | 0.84 | KDM4E (0.54) | DRD2HTR1ADRD3ADRA1AHRH1 | |
| Oxalic Acid SCHEMBL9430076 | 0.83 | ALDH1A1 (0.49) | DRD2HTR1ADRD3ADRA1AHRH1 | |
| Hydrochloric Acid SCHEMBL9428467 | 0.83 | DRD2 (0.57) | DRD2HTR1ADRD3HRH1ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332739-A | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1994-07-26 | — | — | US | disclosed |
| EP-0454498-A2 | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-10-30 | — | — | EP | disclosed |