Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.45 |
| ▸ | PDE4A | P27815 | 5/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429049 | 1.00 | CYSLTR2 (0.45) | CYSLTR2CYSLTR1PDE4APDE4BPDE4C | |
| SCHEMBL9364032 | 0.90 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1PDE4APDE4BPDE4C | |
| SCHEMBL9364026 | 0.90 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1PDE4APDE4BPDE4C | |
| SCHEMBL9429009 | 0.87 | CYSLTR2 (0.41) | CYSLTR2CYSLTR1LMNAKMT2AL3MBTL1 | |
| SCHEMBL9428096 | 0.83 | CYSLTR2 (0.58) | CYSLTR2CYSLTR1PDE4APDE4BPDE4C | |
| SCHEMBL9855528 | 0.83 | CYSLTR2 (0.56) | CYSLTR2CYSLTR1LMNAKMT2AL3MBTL1 | |
| SCHEMBL9364468 | 0.83 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1PDE4APDE4BPDE4C | |
| SCHEMBL9856273 | 0.80 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1LMNAKMT2AL3MBTL1 | |
| SCHEMBL9364503 | 0.80 | CYSLTR2 (0.47) | CYSLTR2CYSLTR1PDE4APDE4BPDE4C | |
| SCHEMBL8937745 | 0.80 | CYSLTR2 (0.47) | CYSLTR2CYSLTR1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0296732-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-09 | — | — | EP | claimed |
| EP-0296732-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1988-12-28 | — | — | EP | claimed |
| US-5314918-A | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1994-05-24 | — | — | US | disclosed |
| EP-0296732-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-09 | — | — | EP | disclosed |
| EP-0403249-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-19 | — | — | EP | disclosed |
| EP-0296732-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1988-12-28 | — | — | EP | disclosed |