Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 12/20 | 0.55 |
| ▸ | PIM1 | P11309 | 2/20 | 0.54 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429827 | 0.94 | HPGD (0.61) | PYGLHPGDPIM1PIM2MAOA | |
| SCHEMBL9312614 | 0.82 | ALDH1A1 (0.38) | PYGLHPGDMAOAMAOB | |
| SCHEMBL9429707 | 0.82 | IGF1R (0.59) | GSK3BHPGDPIM1PIM2 | |
| SCHEMBL9312842 | 0.80 | HPGD (0.61) | HPGDPIM1PIM2MAOAMAOB | |
| SCHEMBL9430681 | 0.77 | FFAR1 (0.48) | HPGD | |
| SCHEMBL9312922 | 0.75 | ALDH1A1 (0.43) | PYGLHPGDMAOB | |
| SCHEMBL6796814 | 0.73 | GSK3B (1.00) | GSK3BHPGDPIM1PIM2MAOA | |
| SCHEMBL2882080 | 0.73 | GSK3B (1.00) | GSK3BHPGDPIM1PIM2MAOA | |
| SCHEMBL2882077 | 0.73 | GSK3B (1.00) | GSK3BHPGDPIM1PIM2MAOA | |
| SCHEMBL1299479 | 0.71 | PIM1 (1.00) | HPGDPIM1PIM2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330999-A | Diabetes, obesity | ADIR ET COMPAGNIE (FR) | 1994-07-19 | — | — | US | disclosed |
| US-5266582-A | Antidiabetic agents | ADIR ET COMPAGNIE (FR) | 1993-11-30 | — | — | US | disclosed |
| EP-0528734-A1 | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-02-24 | — | — | EP | disclosed |